Inhibitory Receptor Expression on T Cells as a Marker of Disease Activity and Target to Regulate Effector Cellular Responses in Rheumatoid Arthritis.
Luisina I OnofrioEstefania R ZaccaPaola FerreroCristina AcostaEduardo MussanoLaura OnettiIsaac CadileM Victoria GazzoniRaúl JuradoJimena Tosello BoariMaria C RamelloCarolina L MontesAdriana GruppiEva Virginia Acosta RodríguezPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2018)
Inhibitory receptor expression on T cells from RA patients is inversely correlated with effector T cell function and disease activity and may predict response to treatment. Furthermore, different inhibitory pathways are functional and cooperatively suppress synovial T cells, providing a rationale for new treatment strategies to regulate acute local inflammation.
Keyphrases
- disease activity
- rheumatoid arthritis
- systemic lupus erythematosus
- rheumatoid arthritis patients
- ankylosing spondylitis
- juvenile idiopathic arthritis
- end stage renal disease
- newly diagnosed
- regulatory t cells
- dendritic cells
- ejection fraction
- oxidative stress
- chronic kidney disease
- liver failure
- peritoneal dialysis
- type iii
- respiratory failure
- clinical trial
- drug induced
- intensive care unit
- extracorporeal membrane oxygenation
- patient reported
- systemic sclerosis