Leishmania infantum induces expression of the negative regulatory checkpoint, CTLA-4, by human naïve CD8+ T cells.
Agostinho Gonçalves VianaLuísa Mourão Dias MagalhãesRodolfo Cordeiro GiunchettiWalderez Ornelas DutraKenneth John GollobPublished in: Parasite immunology (2019)
These results may help explain why patients with the visceral clinical form present a weaker cellular response and, consequently, a worse outcome of the disease. The use of CTLA-4 checkpoint inhibitors may emerge as a potential immunotherapy to ameliorate the immune response in visceral leishmaniasis patients.
Keyphrases
- immune response
- dna damage
- end stage renal disease
- endothelial cells
- ejection fraction
- cell cycle
- chronic kidney disease
- poor prognosis
- newly diagnosed
- prognostic factors
- transcription factor
- insulin resistance
- type diabetes
- dendritic cells
- metabolic syndrome
- binding protein
- adipose tissue
- toll like receptor
- human health
- induced pluripotent stem cells