89Zr-labeled Bispecific T-cell Engager AMG 211 PET Shows AMG 211 Accumulation in CD3-rich Tissues and Clear, Heterogeneous Tumor Uptake.
Kirsten L MoekStijn J H WaaijerIris C KokFrans V SuursAdrienne H BrouwersCatharina Willemien Menke-van der Houven van OordtThijs T WindJourik A GietemaCarolien P SchröderShekar V K MaheshAnnelies Jorritsma-SmitMarjolijn N Lub-de HoogeRudolf S N FehrmannDerk Jan A de GrootElisabeth G E de VriesPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)
This first-in-human study shows high, specific 89Zr-AMG 211 accumulation in CD3-rich lymphoid tissues, as well as a clear, inter- and intraindividual heterogeneous tumor uptake.