Bacteriophage and antibiotic combination therapy for recurrent Enterococcus faecium bacteremia.
Madison E StellfoxCarolyn FernandesRyan K ShieldsGhady HaidarKailey Hughes KramerEmily DembinskiMihnea R MangaleaGarima AryaGregory S CanfieldBreck A DuerkopDaria Van TynePublished in: mBio (2024)
and VRE abundance in the patient's stool. Eventually, an anti-phage antibody response emerged that was able to neutralize phage activity, which may have limited clinical efficacy. This study demonstrates the potential of phages as an additional option in the antimicrobial toolbox for treating invasive enterococcal infections and highlights the need for further investigation to ensure phage therapy can be deployed for maximum clinical benefit.