The Use of External Control Data for Predictions and Futility Interim Analyses in Clinical Trials.

Steffen VentzLeah CommentBill LouvRifaquat RahmanPatrick Y WenBrian M AlexanderLorenzo Trippa

Published in: Neuro-oncology (2021)

Leveraging external data for IAs in RCTs can support early stopping decisions and reduce the number of enrolled patients when the experimental treatment is ineffective.

Keyphrases

clinical trial
end stage renal disease
electronic health record
ejection fraction
newly diagnosed
chronic kidney disease
big data
peritoneal dialysis
prognostic factors
randomized controlled trial
machine learning
deep learning
open label