Cytidine Deaminase Resolves Replicative Stress and Protects Pancreatic Cancer from DNA-Targeting Drugs.

Audrey Lumeau Nicolas Béry Audrey Frances Marion Gayral Guillaume Labrousse Cyril Ribeyre Charlene Lopez Adèle Nevot Abdessamad El Kaoutari Naima Hanoun Emeline Sarot Marion Perrier Frederic Pont Juan Pablo Cerapio Jean-Jacques Fournié Frederic Lopez Miguel Madrid-Mencia Vera Pancaldi Marie-Jeanne Pillaire Valerie Bergoglio Jérôme Torrisani Nelson J Dusetti Jean-Sebastien Hoffmann Louis Buscail Malik Lutzmann Pierre Cordelier

Published in: Cancer research (2024)

Cytidine deaminase reduces replication stress and regulates DNA replication to confer resistance to DNA-damaging drugs in pancreatic cancer, unveiling a molecular vulnerability that could enhance treatment response.

Keyphrases

circulating tumor
single molecule
cell free
climate change
stress induced
nucleic acid
cancer therapy
circulating tumor cells
heat stress
drug induced