Jean-Sebastien Hoffmann (J S Hoffmann, Jean-Sébastien Hoffmann, Jean Sébastien Hoffmann)

ResearcherID ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 26

Top Venues

Cancers

Cancer research

Genes

International journal of molecular sciences

INSERM Délégation régionale Midi-Pyrenees Limousin

University of Toulouse (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

INSERM Délégation régionale Midi-Pyrenees Limousin May 15 1994

France

Team Leader CRCT /Program Leader IUCTO

Institut Universitaire du Cancer Toulouse Oncopole Sep 15 2019 - Sep 15 2021

France

Directeur de Recherche INSERM DR1 - Leader Program of Translational research on Replicative stress and DNA Repair :: Service Anatomopathologie

Education History

University of Toulouse Sep 05 1987 - Jun 11 1991

France

PHD :: CNRS IPBS

Publications

Audrey Lumeau, Nicolas Béry, Audrey Frances, Marion Gayral, Guillaume Labrousse, Cyril Ribeyre, Charlene Lopez, Adèle Nevot, Abdessamad El Kaoutari, Naima Hanoun, Emeline Sarot, Marion Perrier, Frederic Pont, Juan Pablo Cerapio, Jean-Jacques Fournié, Frederic Lopez, Miguel Madrid-Mencia, Vera Pancaldi, Marie-Jeanne Pillaire, Valerie Bergoglio, Jérôme Torrisani, Nelson J Dusetti, Jean-Sebastien Hoffmann, Louis Buscail, Malik Lutzmann, Pierre Cordelier
Cytidine deaminase resolves replicative stress and protects pancreatic cancer from DNA-targeting drugs. Cancer research (2024)
Audrey Lumeau, Nicolas Béry, Audrey Frances, Marion Gayral, Guillaume Labrousse, Cyril Ribeyre, Charlene Lopez, Adèle Nevot, Abdessamad El Kaoutari, Naima Hanoun, Emeline Sarot, Marion Perrier, Frederic Pont, Juan Pablo Cerapio, Jean-Jacques Fournié, Frederic Lopez, Miguel Madrid-Mencia, Vera Pancaldi, Marie-Jeanne Pillaire, Valerie Bergoglio, Jérôme Torrisani, Nelson J Dusetti, Jean-Sebastien Hoffmann, Louis Buscail, Malik Lutzmann, Pierre Cordelier
Cytidine Deaminase Resolves Replicative Stress and Protects Pancreatic Cancer from DNA-Targeting Drugs. Cancer research 84 (7) (2024)
Audrey Lumeau, Nicolas Béry, Audrey Frances, Marion Gayral, Guillaume Labrousse, Cyril Ribeyre, Charlene Lopez, Adèle Nevot, Abdessamad El Kaoutari, Naima Hanoun, Emeline Sarot, Marion Perrier, Frederic Pont, Juan Pablo Cerapio, Jean-Jacques Fournié, Frederic Lopez, Miguel Madrid-Mencia, Vera Pancaldi, Marie-Jeanne Pillaire, Valerie Bergoglio, Jérôme Torrisani, Nelson J Dusetti, Jean-Sebastien Hoffmann, Louis Buscail, Malik Lutzmann, Pierre Cordelier
Cytidine Deaminase Resolves Replicative Stress and Protects Pancreatic Cancer from DNA-Targeting Drugs. Cancer research 84 (7) (2024)
Daniel de Barcellos Azambuja, Helena de Castro E Gloria, Gabriel E Silva Montenegro, Antonio Nocchi Kalil, Jean-Sebastien Hoffmann, Natalia Motta Leguisamo, Jenifer Saffi
High Expression of MRE11A Is Associated with Shorter Survival and a Higher Risk of Death in CRC Patients. Genes 14 (6) (2023)
Daniel de Barcellos Azambuja, Helena de Castro E Gloria, Gabriel E Silva Montenegro, Antonio Nocchi Kalil, Jean-Sebastien Hoffmann, Natalia Motta Leguisamo, Jenifer Saffi
High Expression of MRE11A Is Associated with Shorter Survival and a Higher Risk of Death in CRC Patients. Genes 14 (6) (2023)
Guillaume Labrousse, Pierre Vande Perre, Genis Parra, Marion Jaffrelot, Laura Leroy, Frederic Chibon, Frederic Escudie, Janick Selves, Jean-Sebastien Hoffmann, Rosine Guimbaud, Malik Lutzmann
The hereditary N363K POLE exonuclease mutant extends PPAP tumor spectrum to glioblastomas by causing DNA damage and aneuploidy in addition to increased mismatch mutagenicity. NAR cancer 5 (2) (2023)
Guillaume Labrousse, Pierre Vande Perre, Genis Parra, Marion Jaffrelot, Laura Leroy, Frederic Chibon, Frederic Escudie, Janick Selves, Jean-Sebastien Hoffmann, Rosine Guimbaud, Malik Lutzmann
The hereditary N363K POLE exonuclease mutant extends PPAP tumor spectrum to glioblastomas by causing DNA damage and aneuploidy in addition to increased mismatch mutagenicity. NAR cancer 5 (2) (2023)
Janick Selves, Helena de Castro E Gloria, Anne-Cécile Brunac, Jenifer Saffi, Rosine Guimbaud, Pierre Brousset, Jean-Sebastien Hoffmann
Exploring the basis of heterogeneity of cancer aggressiveness among the mutated POLE variants. Life science alliance 7 (1) (2023)
Daniel de Barcellos Azambuja, Helena de Castro E Gloria, Gabriel E Silva Montenegro, Antonio Nocchi Kalil, Jean-Sebastien Hoffmann, Natalia Motta Leguisamo, Jenifer Saffi
High Expression of MRE11A Is Associated with Shorter Survival and a Higher Risk of Death in CRC Patients. Genes 14 (6) (2023)
Daniel de Barcellos Azambuja, Helena de Castro E Gloria, Gabriel E Silva Montenegro, Antonio Nocchi Kalil, Jean-Sebastien Hoffmann, Natalia Motta Leguisamo, Jenifer Saffi
High Expression of MRE11A Is Associated with Shorter Survival and a Higher Risk of Death in CRC Patients. Genes 14 (6) (2023)
Camille Franchet, Jean-Sebastien Hoffmann, Florence Dalenc
Recent Advances in Enhancing the Therapeutic Index of PARP Inhibitors in Breast Cancer. Cancers 13 (16) (2021)
Jean-Sebastien Hoffmann
The Heritability of Replication Problems. Cells 10 (6) (2021)
Paula Pellenz Tomasini, Temenouga Nikolova Guecheva, Natalia Motta Leguisamo, Sarah Péricart, Anne-Cécile Brunac, Jean-Sebastien Hoffmann, Jenifer Saffi
Analyzing the Opportunities to Target DNA Double-Strand Breaks Repair and Replicative Stress Responses to Improve Therapeutic Index of Colorectal Cancer. Cancers 13 (13) (2021)
Pascale Palassin, Marion Lapierre, Samuel Pyrdziak, Antoine Wagner, Régine Stehle, Carole Corsini, Jacqueline Duffour, Sandrine Bonnet, Abdelhay Boulahtouf, Carmen Rodriguez, Alexandre Ho-Pun-Cheung, Evelyne Lopez-Crapez, Florence Boissière, Frédéric Bibeau, Simon Thezenas, Nabila Elarouci, Janick Selves, Jean-Sebastien Hoffmann, Paul Roepman, Thibault Mazard, Olivier Buhard, Alex Duval, Stéphan Jalaguier, Vincent Cavaillès, Audrey Castet-Nicolas
A Truncated NRIP1 Mutant Amplifies Microsatellite Instability of Colorectal Cancer by Regulating MSH2/MSH6 Expression, and Is a Prognostic Marker of Stage III Tumors. Cancers 13 (17) (2021)
Marina Dall'Osto, Laura Pierini, Nicolas Valery, Jean-Sebastien Hoffmann, Marie-Jeanne Pillaire
A Catalytically Independent Function of Human DNA Polymerase Kappa Controls the Stability and Abundance of Checkpoint Kinase 1. Molecular and cellular biology 41 (11) (2021)
Lilas Courtot, Elodie Bournique, Chrystelle Antoinat Maric, Laure Guitton-Sert, Miguel Madrid-Mencia, Vera Pancaldi, Jean-Charles Cadoret, Jean-Sebastien Hoffmann, Valerie Bergoglio
Low Replicative Stress Triggers Cell-Type Specific Inheritable Advanced Replication Timing. International journal of molecular sciences 22 (9) (2021)
Elisa Mentegari, Federica Bertoletti, Miroslava Kissova, Elisa Zucca, Silvia Galli, Giulia Tagliavini, Anna Garbelli, Antonio Maffia, Silvia Bione, Elena Ferrari, Fabrizio d'Adda di Fagagna, Sofia Francia, Simone Sabbioneda, Liuh-Yow Chen, Joachim Lingner, Valerie Bergoglio, Jean-Sebastien Hoffmann, Ulrich Hübscher, Emmanuele Crespan, Giovanni Maga
A Role for Human DNA Polymerase λ in Alternative Lengthening of Telomeres. International journal of molecular sciences 22 (5) (2021)
Domenico Maiorano, Jana El Etri, Camille Franchet, Jean-Sebastien Hoffmann
Translesion Synthesis or Repair by Specialized DNA Polymerases Limits Excessive Genomic Instability upon Replication Stress. International journal of molecular sciences 22 (8) (2021)
Jian Li, Josephine Mun-Yee Ko, Wei Dai, Valen Zhuoyou Yu, Hoi Yan Ng, Jean-Sebastien Hoffmann, Maria Li Lung
Depletion of DNA Polymerase Theta Inhibits Tumor Growth and Promotes Genome Instability through the cGAS-STING-ISG Pathway in Esophageal Squamous Cell Carcinoma. Cancers 13 (13) (2021)
Pierre-Luc Mouchel, Nizar Serhan, Rémy Betous, Thomas Farge, Estelle Saland, Philippe De Medina, Jean-Sebastien Hoffmann, Jean-Emmanuel Sarry, Marc Poirot, Sandrine Silvente-Poirot, Christian Recher
Dendrogenin A Enhances Anti-Leukemic Effect of Anthracycline in Acute Myeloid Leukemia. Cancers 12 (10) (2020)
Agustina P Bertolin, Jean-Sebastien Hoffmann, Vanesa Gottifredi
Under-Replicated DNA: The Byproduct of Large Genomes? Cancers 12 (10) (2020)
Mélanie K Prodhomme, Roxane M Pommier, Camille Franchet, Frédérique Fauvet, Valerie Bergoglio, Pierre Brousset, Anne-Pierre Morel, Anne Cecile Brunac, Mojgan Devouassoux-Shisheboran, Virginie Petrilli, Caroline Moyret-Lalle, Jean-Sebastien Hoffmann, Alain Puisieux, Agnès Tissier
EMT Transcription Factor ZEB1 Represses the Mutagenic POLθ-Mediated End-Joining Pathway in Breast Cancers. Cancer research 81 (6) (2020)
Julien N Bianco, Valérie Bergoglio, Yea-Lih Lin, Marie-Jeanne Pillaire, Anne-Lyne Schmitz, Julia Gilhodes, Amelie Lusque, Julien Mazières, Magali Lacroix-Triki, Theodoros I Roumeliotis, Jyoti Choudhary, Jérôme Moreaux, Jean-Sebastien Hoffmann, Hélène Tourrière, Philippe Pasero
Overexpression of Claspin and Timeless protects cancer cells from replication stress in a checkpoint-independent manner. Nature communications 10 (1) (2019)
Marina A González Besteiro, Nicolás L Calzetta, Sofía M Loureiro, Martín Habif, Rémy Bétous, Marie-Jeanne Pillaire, Antonio Maffia, Simone Sabbioneda, Jean-Sebastien Hoffmann, Vanesa Gottifredi
Chk1 loss creates replication barriers that compromise cell survival independently of excess origin firing. The EMBO journal 38 (16) (2019)
Rémy Bétous, Théo Goullet de Rugy, Alessandra Luiza Pelegrini, Sophie Queille, Jean Pierre de Villartay, Jean-Sebastien Hoffmann
DNA replication stress triggers rapid DNA replication fork breakage by Artemis and XPF. PLoS genetics 14 (7) (2018)
T Goullet de Rugy, M Bashkurov, A Datti, R Betous, L Guitton-Sert, C Cazaux, D Durocher, Jean-Sebastien Hoffmann
Excess Polθ functions in response to replicative stress in homologous recombination-proficient cancer cells. Biology open 5 (10) (2016)

Jean-Sebastien Hoffmann.css-eqlu8i{font-size:small;padding-left:4px;} (J S Hoffmann, Jean-Sébastien Hoffmann, Jean Sébastien Hoffmann)

Publication Activity (10 Years)

Top Topics

Top Venues

Jean-Sebastien Hoffmann (J S Hoffmann, Jean-Sébastien Hoffmann, Jean Sébastien Hoffmann)