The effects of dietary polyunsaturated fatty acids on miR-126 promoter DNA methylation status and VEGF protein expression in the colorectal cancer cells.

Mostafa Moradi SarabiSeyed Abdollah ZahediNaser PajouhiPeyman KhosraviShahrokh BagheriHassan AhmadvandSoroosh Shahryarhesami

Published in: Genes & nutrition (2018)

Our results provide evidence that n-3 PUFAs are able to modulate cellular miR-126 DNA methylation and inhibit VEGF expression level in a cell-type specific manner in colorectal cancer cells. DHA always showed higher efficacy than EPA and LA in our experiment. Overall, our results suggest a potential clinical application of n-3 PUFAs as anti-angiogenic agents in CRC therapy.

Keyphrases

dna methylation
long non coding rna
cell proliferation
poor prognosis
genome wide
vascular endothelial growth factor
gene expression
long noncoding rna
endothelial cells
copy number
stem cells
transcription factor
bone marrow
mesenchymal stem cells
climate change