SMYD2-Methylated PPARγ Facilitates Hypoxia-Induced Pulmonary Hypertension by Activating Mitophagy.
Yi LiXiang WeiRui XiaoYongjie ChenTianxin XiongZe-Min FangBo HuoXian GuoHanshen LuoXingliang WuLiyuan LiuXue-Hai ZhuQinghua HuDing-Sheng JiangXin YiPublished in: Circulation research (2024)
Our results demonstrated that SMYD2 monomethylates nonhistone PPARγ and inhibits its nuclear translocation and activation to accelerate PASMC proliferation and PH by triggering mitophagy, indicating that targeting SMYD2 or activating PPARγ are potential strategies for the prevention of PH.