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Multi-omics signatures of the human early life exposome.

Lea MaitreMariona BustamanteCarles Hernandez-FerrerDenise ThielChung-Ho E LauAlexandros P SiskosMarta Vives-UsanoCarlos Ruiz-ArenasDolors Pelegrí-SisóOliver RobinsonDan MasonJohn WrightSolène CadiouRémy SlamaBarbara HeudeMaribel CasasJordi SunyerEleni Z PapadopoulouKristine B GutzkowRegina GrazulevicieneRegina GrazulevicieneMarina VafeiadiLeda ChatziAmrit K SakhiCathrine ThomsenIbon TamayoMark NieuwenhuijsenJose UrquizaEva BorràsEduard SabidóInés QuintelaÁngel CarracedoXavier EstivillMuireann CoenJuan Ramon GonzálezHector C KeunMartine Vrijheid
Published in: Nature communications (2022)
Environmental exposures during early life play a critical role in life-course health, yet the molecular phenotypes underlying environmental effects on health are poorly understood. In the Human Early Life Exposome (HELIX) project, a multi-centre cohort of 1301 mother-child pairs, we associate individual exposomes consisting of >100 chemical, outdoor, social and lifestyle exposures assessed in pregnancy and childhood, with multi-omics profiles (methylome, transcriptome, proteins and metabolites) in childhood. We identify 1170 associations, 249 in pregnancy and 921 in childhood, which reveal potential biological responses and sources of exposure. Pregnancy exposures, including maternal smoking, cadmium and molybdenum, are predominantly associated with child DNA methylation changes. In contrast, childhood exposures are associated with features across all omics layers, most frequently the serum metabolome, revealing signatures for diet, toxic chemical compounds, essential trace elements, and weather conditions, among others. Our comprehensive and unique resource of all associations ( https://helixomics.isglobal.org/ ) will serve to guide future investigation into the biological imprints of the early life exposome.
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