Exploiting WEE1 kinase activity as FUS::DDIT3-dependent therapeutic vulnerability in myxoid liposarcoma.

Lorena Heinst Kwang-Seok Lee Ruth Berthold Ilka Isfort Svenja Wosnig Anna Kuntze Susanne Hafner Bianca Altvater Claudia Rossig Pierre Aman Eva Wardelmann Claudia Scholl Wolfgang Hartmann Stefan Fröhling Marcel Trautmann

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

Our preclinical study identifies WEE1-mediated replication stress tolerance as molecular vulnerability in FUS::DDIT3-driven MLS tumorigenesis that could represent a novel target for therapeutic intervention.

Keyphrases

climate change
randomized controlled trial
genome wide
stem cells
tyrosine kinase
protein kinase
bone marrow