Impact of retrotransposon protein L1 ORF1p expression on oncogenic pathways in hepatocellular carcinoma: the role of cytoplasmic PIN1 upregulation.

Bassier ZadranPraveen Dhondurao SudhindarDaniel WainwrightYvonne BurySaimir LuliRachel HowarthMisti Vanette McCainRobyn WatsonHannah HuetFanni PalinkasRolando Berlinguer PalminiJohn CasementDerek A MannFiona OakleyJohn LunecHelen ReevesGeoffrey J Faulkner Ruchi Shukla

Published in: British journal of cancer (2023)

Our data demonstrate a causal link between L1 ORF1p and key oncogenic pathways mediated by PIN1, presenting a novel therapeutic avenue.

Keyphrases

poor prognosis
transcription factor
binding protein
electronic health record
long non coding rna
cell proliferation
signaling pathway
case report