Adipocyte-derived inflammatory molecules induce senescent B cells through metabolic pathways.

Daniela FrascaMaria RomeroDenisse GarciaSeth ThallerValquiria Bueno

Published in: Obesity (Silver Spring, Md.) (2024)

These results demonstrate that B cells from lean individuals, after incubation with ACM, become inflammatory and senescent, and this occurs through metabolic pathways needed to support their secretory phenotype.

Keyphrases

oxidative stress
adipose tissue
insulin resistance
fatty acid
type diabetes
bone mineral density
metabolic syndrome