Neuroimaging of Anxiety in Parkinson's Disease: A Systematic Review.
Guillaume CareyMeltem GörmezoğluJoost J A de JongPaul A M HofmanWalter H BackesKathy DujardinAlbert F G LeentjensPublished in: Movement disorders : official journal of the Movement Disorder Society (2020)
To conclude, anxiety is associated with structural and functional changes in both the hypothesized fear and the limbic cortico-striato-thalamocortical circuits. These circuits overlap and may well constitute parts of a more extensive pathway, of which different parts play different roles in anxiety. The neuropathology of PD may affect these circuits in different ways, explaining the high prevalence of anxiety in PD and also the associated cognitive, motor, and psychiatric symptoms. © 2020 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.