The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.

Wenhu ChenLiqiang HuXuemei LuXiaofei WangChangan ZhaoChen GuoXiaoyan LiYuqin DingHongguang ZhaoDongdong TongLifang WangChen Huang

Published in: Breast cancer research and treatment (2023)

Our results indicate that MEX3A plays a prominent oncogenic role in BC tumorigenesis and progression by targeting IGFBP4 mRNA and activating PI3K/AKT signaling, which can be used as a novel therapeutic target for BC.

Keyphrases

pi k akt
signaling pathway
binding protein
cell cycle arrest
cell proliferation
poor prognosis
transcription factor
young adults
cell death
nucleic acid