The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.
Wenhu ChenLiqiang HuXuemei LuXiaofei WangChangan ZhaoChen GuoXiaoyan LiYuqin DingHongguang ZhaoDongdong TongLifang WangChen HuangPublished in: Breast cancer research and treatment (2023)
Our results indicate that MEX3A plays a prominent oncogenic role in BC tumorigenesis and progression by targeting IGFBP4 mRNA and activating PI3K/AKT signaling, which can be used as a novel therapeutic target for BC.