The association of PD-L1 expression and CD8-positive T cell infiltration rate with the pathological complete response after neoadjuvant treatment in HER2-positive breast cancer.
Kenan ÇetinSermin Coban KoktenBahar SarıkamışSedat YıldırımOruç Numan GökçeNagehan Özdemir BarışıkÜlkan KılıçPublished in: Breast cancer research and treatment (2024)
High Ki-67 index, and high CD8 cell count are strong predictors for pCR in HER2-positive breast cancer. Tumours with high Ki-67 index, high TILs and CD8 infiltration may represent a subgroup where standard therapies are adequate. Conversely, those with low TILs and CD8 infiltration may identify a subgroup where use of novel strategies, including those that increase CD8 infiltration could be applied.