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Seasonal coronavirus protective immunity is short-lasting.

Arthur Wouter Dante EdridgeJoanna KaczorowskaAlexis C R HosteMargreet BakkerMichelle KleinKatherine LoensMaarten F JebbinkAmy MatserCormac M KinsellaPaloma RuedaMargareta IevenHerman GoossensMaria PrinsPatricia SastreMartin DeijsLia van der Hoek
Published in: Nature medicine (2020)
A key unsolved question in the current coronavirus disease 2019 (COVID-19) pandemic is the duration of acquired immunity. Insights from infections with the four seasonal human coronaviruses might reveal common characteristics applicable to all human coronaviruses. We monitored healthy individuals for more than 35 years and determined that reinfection with the same seasonal coronavirus occurred frequently at 12 months after infection.
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