Activation of Piezo1 contributes to matrix stiffness-induced angiogenesis in hepatocellular carcinoma.

Miao LiXi ZhangMimi WangYaohui WangJiali QianXiaoxia XingZhiming WangYang YouKun GuoJie ChenDongmei GaoYan ZhaoLan ZhangRongxin ChenJiefeng CuiZhenggang Ren

Published in: Cancer communications (London, England) (2022)

This study unravels a new mechanism by which the integrin β1/Piezo1 activation/Ca<sup>2+</sup> influx/HIF-1α ubiquitination/VEGF, CXCL16 and IGFBP2 pathway participates in matrix stiffness-driven HCC angiogenesis. Simultaneously, a positive feedback regulation loop as stiff matrix/integrin β1/miR-625-5p/Piezo1 and COL1/stiffer matrix mediates matrix stiffness-caused Piezo1 upregulation.

Keyphrases

endothelial cells
vascular endothelial growth factor
high glucose
poor prognosis
transcription factor
oxidative stress
cell adhesion