Low-Frequency Magnetic Resonance Imaging Identifies Hand Joint Subclinical Inflammation in Systemic Sclerosis.
Bojana N StamenkovicSonja StojanovicValentina ZivkovicDragan DjordjevicMila BojanovicAleksandra StankovicNatasa Krsto RancicNemanja DamjanovMarco Matucci CerinicPublished in: Diagnostics (Basel, Switzerland) (2022)
Our data show that in SSc MRI can detect a significant subclinical joint inflammation. RAMRIS confirmed the high degree of joint inflammation in RA, but also revealed a great deal of joint inflammation in SSc. That inflammation is associated with systemic inflammation (disease activity), vascular complications, and more severe forms of the disease, as synovitis cannot be precisely diagnosed by the clinical examination of joints. These results suggest that a careful joint investigation is necessary in SSc, and that in symptomatic patients, MRI may identify joint inflammation. In clinical practice, this evidence might drive to an early targeted therapy, thus preventing joint erosions.
Keyphrases
- oxidative stress
- magnetic resonance imaging
- systemic sclerosis
- disease activity
- rheumatoid arthritis
- clinical practice
- systemic lupus erythematosus
- contrast enhanced
- ankylosing spondylitis
- rheumatoid arthritis patients
- ejection fraction
- chronic kidney disease
- risk factors
- genome wide
- prognostic factors
- machine learning
- electronic health record
- juvenile idiopathic arthritis
- data analysis