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Equally potent: Nlrp3 mutation in macrophages or neutrophils is sufficient to drive autoinflammation.

Kaiwen W Chen
Published in: EMBO reports (2022)
Gain-of-function mutation in NLRP3 is associated with a spectrum of autoinflammatory disorders including familial cold autoinflammatory syndrome, Muckle-Wells syndrome, and neonatal onset multisystem inflammatory disease, collectively known as cryopyrin-associated periodic syndrome (CAPS). However, the cell types mediating the pathogenesis of CAPS are not completely understood. Two studies in EMBO Reports now demonstrate that gain-of-function Nlrp3 mutation in either macrophages or neutrophils alone is sufficient to trigger systemic autoinflammation and lethality in mice.
Keyphrases
  • case report
  • nlrp inflammasome
  • single cell
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  • type diabetes
  • stem cells
  • early onset
  • bone marrow
  • adipose tissue
  • mesenchymal stem cells
  • metabolic syndrome
  • anti inflammatory
  • high fat diet induced