Kaiwen W Chen

Scopus Author ID ResearcherID Loop profile ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 25

Top Venues

Cell death & disease

Proceedings of the National Academy of Sciences of the United States of America

The EMBO journal

Science advances

University of Lausanne

University of Queensland (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Lausanne Jan 01 2018

Switzerland

Postdoc :: Department of Biochemistry

Education History

University of Queensland Sep 05 2011 - Oct 24 2015

Australia

PHD :: Institute for Molecular Bioscience

Publications

Jascinta P Santavanond, Yu-Hsin Chiu, Rochelle Tixeira, Zonghan Liu, Jeremy K Y Yap, Kaiwen W Chen, Chen-Lu Li, Yi-Ru Lu, Joan Roncero-Carol, Esteban Hoijman, Stephanie F Rutter, Bo Shi, Gemma F Ryan, Amy L Hodge, Sarah Caruso, Amy A Baxter, Dilara C Ozkocak, Chad Johnson, Zoe I Day, Alyce J Mayfosh, Mark D Hulett, Thanh Kha Phan, Georgia K Atkin-Smith, Ivan K H Poon
The small molecule raptinal can simultaneously induce apoptosis and inhibit PANX1 activity. Cell death & disease 15 (2) (2024)
Kaiwen W Chen, Petr Broz
Gasdermins as evolutionarily conserved executors of inflammation and cell death. Nature cell biology (2024)
See Jie Yow, Safwah Nasuha Rosli, Paul E Hutchinson, Kaiwen W Chen
Differential signalling requirements for RIPK1-dependent pyroptosis in neutrophils and macrophages. Cell death & disease 15 (7) (2024)
Jascinta P Santavanond, Yu-Hsin Chiu, Rochelle Tixeira, Zonghan Liu, Jeremy K Y Yap, Kaiwen W Chen, Chen-Lu Li, Yi-Ru Lu, Joan Roncero-Carol, Esteban Hoijman, Stephanie F Rutter, Bo Shi, Gemma F Ryan, Amy L Hodge, Sarah Caruso, Amy A Baxter, Dilara C Ozkocak, Chad Johnson, Zoe I Day, Alyce J Mayfosh, Mark D Hulett, Thanh Kha Phan, Georgia K Atkin-Smith, Ivan K H Poon
The small molecule raptinal can simultaneously induce apoptosis and inhibit PANX1 activity. Cell death & disease 15 (2) (2024)
Jascinta P Santavanond, Yu-Hsin Chiu, Rochelle Tixeira, Zonghan Liu, Jeremy K Y Yap, Kaiwen W Chen, Chen-Lu Li, Yi-Ru Lu, Joan Roncero-Carol, Esteban Hoijman, Stephanie F Rutter, Bo Shi, Gemma F Ryan, Amy L Hodge, Sarah Caruso, Amy A Baxter, Dilara C Ozkocak, Chad Johnson, Zoe I Day, Alyce J Mayfosh, Mark D Hulett, Thanh Kha Phan, Georgia K Atkin-Smith, Ivan K H Poon
The small molecule raptinal can simultaneously induce apoptosis and inhibit PANX1 activity. Cell death & disease 15 (2) (2024)
Jascinta P Santavanond, Yu-Hsin Chiu, Rochelle Tixeira, Zonghan Liu, Jeremy K Y Yap, Kaiwen W Chen, Chen-Lu Li, Yi-Ru Lu, Joan Roncero-Carol, Esteban Hoijman, Stephanie F Rutter, Bo Shi, Gemma F Ryan, Amy L Hodge, Sarah Caruso, Amy A Baxter, Dilara C Ozkocak, Chad Johnson, Zoe I Day, Alyce J Mayfosh, Mark D Hulett, Thanh Kha Phan, Georgia K Atkin-Smith, Ivan K H Poon
The small molecule raptinal can simultaneously induce apoptosis and inhibit PANX1 activity. Cell death & disease 15 (2) (2024)
Jascinta P Santavanond, Yu-Hsin Chiu, Rochelle Tixeira, Zonghan Liu, Jeremy K Y Yap, Kaiwen W Chen, Chen-Lu Li, Yi-Ru Lu, Joan Roncero-Carol, Esteban Hoijman, Stephanie F Rutter, Bo Shi, Gemma F Ryan, Amy L Hodge, Sarah Caruso, Amy A Baxter, Dilara C Ozkocak, Chad Johnson, Zoe I Day, Alyce J Mayfosh, Mark D Hulett, Thanh Kha Phan, Georgia K Atkin-Smith, Ivan K H Poon
The small molecule raptinal can simultaneously induce apoptosis and inhibit PANX1 activity. Cell death & disease 15 (2) (2024)
See Jie Yow, Safwah Nasuha Rosli, Paul E Hutchinson, Kaiwen W Chen
Differential signalling requirements for RIPK1-dependent pyroptosis in neutrophils and macrophages. Cell death & disease 15 (7) (2024)
See Jie Yow, Safwah Nasuha Rosli, Paul E Hutchinson, Kaiwen W Chen
Differential signalling requirements for RIPK1-dependent pyroptosis in neutrophils and macrophages. Cell death & disease 15 (7) (2024)
See Jie Yow, Safwah Nasuha Rosli, Paul E Hutchinson, Kaiwen W Chen
Differential signalling requirements for RIPK1-dependent pyroptosis in neutrophils and macrophages. Cell death & disease 15 (7) (2024)
Hui Wen Yeap, Kaiwen W Chen
RIPK1 and RIPK3 in antibacterial defence. Biochemical Society transactions (2022)
See Jie Yow, Hui Wen Yeap, Kaiwen W Chen
Inflammasome and gasdermin signaling in neutrophils. Molecular microbiology 117 (5) (2022)
Kim Samirah Robinson, Gee Ann Toh, Pritisha Rozario, Rae Chua, Stefan Bauernfried, Zijin Sun, Muhammad Jasrie Firdaus, Shima Bayat, Rhea Nadkarni, Zhi Sheng Poh, Khek-Chian Tham, Cassandra R Harapas, Chrissie Kaishi Lim, Werncui Chu, Celest W S Tay, Kiat-Yi Tan, Tianyun Zhao, Carine Bonnard, Radoslaw Mikolaj Sobota, John E Connolly, John Edmund Armourer Common, Seth L Masters, Kaiwen W Chen, Lena Ho, Bin Wu, Veit Hornung, Franklin Lei Zhong
ZAKα-driven ribotoxic stress response activates the human NLRP1 inflammasome. Science (New York, N.Y.) 377 (6603) (2022)
Kaiwen W Chen
Equally potent: Nlrp3 mutation in macrophages or neutrophils is sufficient to drive autoinflammation. EMBO reports 23 (11) (2022)
Elisabet Bjanes, Reyna Garcia Sillas, Rina Matsuda, Benjamin Demarco, Timothée Fettrelet, Alexandra A DeLaney, Opher S Kornfeld, Bettina L Lee, Eric M Rodríguez López, Daniel Grubaugh, Meghan A Wynosky-Dolfi, Naomi H Philip, Elise Krespan, Dorothy Tovar, Leonel Joannas, Daniel P Beiting, Jorge Henao-Mejia, Brian C Schaefer, Kaiwen W Chen, Petr Broz, Igor E Brodsky
Genetic targeting of Card19 is linked to disrupted NINJ1 expression, impaired cell lysis, and increased susceptibility to Yersinia infection. PLoS pathogens 17 (10) (2021)
Kaiwen W Chen, Benjamin Demarco, Saray Ramos, Rosalie Heilig, Michiel Goris, James P Grayczyk, Charles-Antoine Assenmacher, Enrico Radaelli, Leonel D Joannas, Jorge Henao-Mejia, Fabienne Tacchini-Cottier, Igor E Brodsky, Petr Broz
RIPK1 activates distinct gasdermins in macrophages and neutrophils upon pathogen blockade of innate immune signaling. Proceedings of the National Academy of Sciences of the United States of America 118 (28) (2021)
Kaiwen W Chen, Dave Boucher, Petr Broz
Divide to conquer: NLRP3 is activated on dispersed trans-Golgi network. Cell research 29 (3) (2020)
Rosalie Heilig, Marisa Dilucca, Dave Boucher, Kaiwen W Chen, Dora Hancz, Benjamin Demarco, Kateryna Shkarina, Petr Broz
Caspase-1 cleaves Bid to release mitochondrial SMAC and drive secondary necrosis in the absence of GSDMD. Life science alliance 3 (6) (2020)
José Carlos Santos, Dave Boucher, Larisa Kapinos Schneider, Benjamin Demarco, Marisa Dilucca, Kateryna Shkarina, Rosalie Heilig, Kaiwen W Chen, Roderick Y H Lim, Petr Broz
Human GBP1 binds LPS to initiate assembly of a caspase-4 activating platform on cytosolic bacteria. Nature communications 11 (1) (2020)
Benjamin Demarco, James P Grayczyk, Elisabet Bjanes, Didier Le Roy, Wulf Tonnus, Charles-Antoine Assenmacher, Enrico Radaelli, Timothée Fettrelet, Vanessa Mack, Andreas Linkermann, Thierry Roger, Igor E Brodsky, Kaiwen W Chen, Petr Broz
Caspase-8-dependent gasdermin D cleavage promotes antimicrobial defense but confers susceptibility to TNF-induced lethality. Science advances 6 (47) (2020)
Kaiwen W Chen, Benjamin Demarco, Petr Broz
Beyond inflammasomes: emerging function of gasdermins during apoptosis and NETosis. The EMBO journal 39 (2) (2019)
Kaiwen W Chen, Benjamin Demarco, Petr Broz
Pannexin-1 promotes NLRP3 activation during apoptosis but is dispensable for canonical or noncanonical inflammasome activation. European journal of immunology 50 (2) (2019)
Benjamin Demarco, Kaiwen W Chen, Petr Broz
Pannexin-1 channels bridge apoptosis to NLRP3 inflammasome activation. Molecular & cellular oncology 6 (4) (2019)
Kaiwen W Chen, Mercedes M Monteleone, Dave Boucher, Gabriel Sollberger, Divya Ramnath, Nicholas D Condon, Jessica B von Pein, Petr Broz, Matthew J Sweet, Kate Schroder
Noncanonical inflammasome signaling elicits gasdermin D-dependent neutrophil extracellular traps. Science immunology 3 (26) (2019)
Stephanie A Conos, Kaiwen W Chen, Dominic De Nardo, Hideki Hara, Lachlan Whitehead, Gabriel Núñez, Seth L Masters, James M Murphy, Kate Schroder, David L Vaux, Kate E Lawlor, Lisa M Lindqvist, James E Vince
Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner. Proceedings of the National Academy of Sciences of the United States of America 114 (6) (2017)

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Publication Activity (10 Years)

Top Topics

Top Venues

Kaiwen W Chen