The endocannabinoid system is composed by a complex and ubiquitous network of endogenous lipid ligands, enzymes for their synthesis and degradation, and receptors, which can also be stimulated by exogenous compounds, such as those derived from the Cannabis sativa. Cannabis and its bioactive compounds, including cannabinoids and non-cannabinoids, have been extensively studied in different conditions. Recent data have shown that the endocannabinoid system is responsible for maintaining the homeostasis of various skin functions such as proliferation, differentiation and release of inflammatory mediators. Because of their role in regulating these key processes, cannabinoids have been studied for the treatment of skin cancers and melanoma; their anti-tumour effects regulate skin cancer progression and are mainly related to the inhibition of tumour growth, proliferation, invasion and angiogenesis, through apoptosis and autophagy induction. This review aims at summarising the current field of research on the potential uses of cannabinoids in the melanoma field.
Keyphrases
- skin cancer
- signaling pathway
- oxidative stress
- endoplasmic reticulum stress
- cell death
- wound healing
- soft tissue
- endothelial cells
- multidrug resistant
- electronic health record
- fatty acid
- cell proliferation
- big data
- climate change
- combination therapy
- basal cell carcinoma
- young adults
- deep learning
- human health
- data analysis
- network analysis