HDAC class I inhibitor, Mocetinostat, reverses cardiac fibrosis in heart failure and diminishes CD90+ cardiac myofibroblast activation.

Hikmet F Nural-GuvenerLuidmila ZakharovaJames NimlosSnjezana PopovicDiego MastroeniMohamed A Gaballa

Published in: Fibrogenesis & tissue repair (2014)

Taken together, our results demonstrate upregulation of HDAC1 and 2 in CHF. In addition, HDAC inhibition reverses interstitial fibrosis in CHF. Possible anti-fibrotic actions of HDAC inhibition include reversal of myofibroblast activation and induction of cell cycle arrest/apoptosis.

Keyphrases

cell cycle arrest
histone deacetylase
cell death
heart failure
left ventricular
pi k akt
transforming growth factor
oxidative stress
poor prognosis
pulmonary fibrosis
liver fibrosis
cardiac resynchronization therapy
nk cells