The multicellular signalling network of ovarian cancer metastases.

Leah SommerfeldFlorian FinkernagelJulia M JansenUwe WagnerAndrea NistThorsten StieweSabine Müller-BrüsselbachAnna M SokolJohannes GraumannSilke ReinartzRolf Müller

Published in: Clinical and translational medicine (2022)

The intercellular signaling network of omental metastases is majorly dependent on factors secreted by immune and stroma cells to provide an environment that supports ovarian HGSC progression. Clinically relevant pathways within this network represent novel options for therapeutic intervention.

Keyphrases

induced apoptosis
randomized controlled trial
cell cycle arrest
signaling pathway
oxidative stress
network analysis
endoplasmic reticulum stress
cell adhesion