The overexpression of AUF1 in colorectal cancer predicts a poor prognosis and promotes cancer progression by activating ERK and AKT pathways.

Xin-Yuan TianJin LiTeng-Hui LiuDan-Ni LiJing-Jing WangHe ZhangZhou-Lu DengFu-Jun ChenJian-Ping Cai

Published in: Cancer medicine (2020)

Our findings demonstrate that AUF1 is probably involved in the progression of CRC via the activation of the ERK1/2 and AKT pathways. AU-rich RNA-binding factor 1 could be used as a novel prognostic biomarker and a potential therapeutic target for CRC.

Keyphrases

signaling pathway
poor prognosis
cell proliferation
long non coding rna
pi k akt
papillary thyroid
squamous cell
sensitive detection
climate change
gold nanoparticles
reduced graphene oxide
human health
binding protein
lymph node metastasis
dna binding
visible light