A population-based incidence of M2 strokes indicates potential expansion of large vessel occlusions amenable to endovascular therapy.

M2 occlusions can present with serious neurological deficits and cause significant morbidity and mortality. Patients with M2 occlusions and higher baseline deficits (NIHSS score ≥9) may benefit from endovascular therapy, thus potentially expanding the category of acute ischemic strokes amenable to intervention.