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Optimizing de-escalation of inhaled corticosteroids in COPD: a systematic review of real-world findings.

Rogliani PaolaBeatrice Ludovica RitondoMariachiara GabrieleMario CazzolaLuigino Calzetta
Published in: Expert review of clinical pharmacology (2020)
De-escalation to ICS is a procedure that allows optimizing the pharmacological therapy of stable COPD patients. While only a minority of severe COPD patients that are symptomatic and/or at high risk of exacerbation may really need of triple therapy, most patients should be de-escalated/switched from ICS-containing regimen toward dual bronchodilator therapy, or even to single bronchodilator regimen in patients affected by less severe form of COPD.
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