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Regulation of Autophagy via Carbohydrate and Lipid Metabolism in Cancer.

Javad AlizadehMahboubeh KavoosiNavjit SinghShahrokh LorzadehAmir RavandiBiniam KidaneNaseer AhmedFatima MraicheMichael R A MowatSaeid Ghavmi
Published in: Cancers (2023)
Metabolic changes are an important component of tumor cell progression. Tumor cells adapt to environmental stresses via changes to carbohydrate and lipid metabolism. Autophagy, a physiological process in mammalian cells that digests damaged organelles and misfolded proteins via lysosomal degradation, is closely associated with metabolism in mammalian cells, acting as a meter of cellular ATP levels. In this review, we discuss the changes in glycolytic and lipid biosynthetic pathways in mammalian cells and their impact on carcinogenesis via the autophagy pathway. In addition, we discuss the impact of these metabolic pathways on autophagy in lung cancer.
Keyphrases
  • cell death
  • endoplasmic reticulum stress
  • signaling pathway
  • oxidative stress
  • fatty acid
  • cell therapy
  • squamous cell carcinoma
  • stem cells
  • single cell
  • lymph node metastasis