TGF-β-induced activation of conjunctival fibroblasts is modulated by FGF-2 and substratum stiffness.

Tomoyo MatsumuraTomokazu FujimotoAkiko FutakuchiYuji TakiharaFumika Watanabe-KitamuraEri TakahashiMiyuki Inoue-MochitaHidenobu TaniharaToshihiro Inoue

Published in: PloS one (2020)

FGF-2 treatment and a soft substratum suppressed TGF-β-induced transdifferentiation of conjunctival fibroblasts into myofibroblasts. FGF-2 attenuated the TGF-β-induced expression of α-SMA, even on a soft substratum.

Keyphrases

high glucose
diabetic rats
transforming growth factor
drug induced
poor prognosis
oxidative stress
long non coding rna
combination therapy