TGF-β-induced activation of conjunctival fibroblasts is modulated by FGF-2 and substratum stiffness.
Tomoyo MatsumuraTomokazu FujimotoAkiko FutakuchiYuji TakiharaFumika Watanabe-KitamuraEri TakahashiMiyuki Inoue-MochitaHidenobu TaniharaToshihiro InouePublished in: PloS one (2020)
FGF-2 treatment and a soft substratum suppressed TGF-β-induced transdifferentiation of conjunctival fibroblasts into myofibroblasts. FGF-2 attenuated the TGF-β-induced expression of α-SMA, even on a soft substratum.