Ovalbumin Hydrolysates Enhance Skeletal Muscle Insulin-Dependent Signaling Pathway in High-Fat Diet-Fed Mice.
Nesma ElhadadS C de Campos ZaniC B ChanJianping WuPublished in: Journal of agricultural and food chemistry (2024)
Egg white hydrolysates (EWH) and ovotransferrin-derived peptides have distinct beneficial effects on glucose metabolism. This research aims to investigate whether ovalbumin hydrolysates (OVAHs), without ovotransferrin can improve insulin signaling pathway in high-fat diet (HFD)-fed mice. Two types of ovalbumin hydrolysates were produced, either using thermoase (OVAT), or thermoase + pepsin (OVATP). Both OVAHs-supplemented groups exhibited lower body weight gain ( P < 0.001) and enhanced oral glucose tolerance ( P < 0.05) compared with HFD. Moreover, diet supplementation with either hydrolysate increased the insulin-stimulated activation of protein kinase B (AKT) and insulin receptor β (IRβ) ( P < 0.0001) in skeletal muscle. In conclusion, OVAHs improved glucose tolerance and insulin-dependent signaling pathway in HFD-fed mice.
Keyphrases
- high fat diet
- insulin resistance
- type diabetes
- signaling pathway
- high fat diet induced
- skeletal muscle
- adipose tissue
- glycemic control
- weight gain
- pi k akt
- epithelial mesenchymal transition
- body mass index
- metabolic syndrome
- weight loss
- protein kinase
- physical activity
- cell proliferation
- birth weight
- oxidative stress