Hepatocyte high-mobility group box 1 protects against steatosis and cellular stress during high fat diet feeding.

Minjie LinJungke LongWenbo LiChenxuan YangPatricia LoughranRobert O'DohertyTimothy R BilliarMeihong DengMelanie J Scott

Published in: Molecular medicine (Cambridge, Mass.) (2020)

Our findings suggest that hepatocyte HMGB1 protects against dysregulated lipid metabolism via maintenance of β-oxidation and prevention of ER stress. This represents a novel mechanism for HMGB1-regulation of hepatocellular steatosis, and suggests that stabilizing HMGB1 in hepatocytes may be effective strategies for prevention and treatment of NAFLD.

Keyphrases

high fat diet
insulin resistance
adipose tissue
liver injury
drug induced
transcription factor
type diabetes
metabolic syndrome
skeletal muscle
high fat diet induced
binding protein
combination therapy
fatty acid
nitric oxide
stress induced
heat stress