Transcriptional immunogenomic analysis reveals distinct immunological clusters in paediatric nervous system tumours.

Arash NabbiPengbo BeckAlberto DelaidelliDerek A OldridgeSumedha SudhamanKelsey ZhuS Y Cindy YangDavid T MulderJeffrey P BruceJoseph N PaulsonPichai RamanYuankun ZhuAdam C ResnickPoul H SorensenMartin SillSebastian BrabetzSander LamboDavid MalkinPascal D JohannMarcel KoolDavid T W JonesStefan M PfisterNatalie JägerTrevor J Pugh

Published in: Genome medicine (2023)

Given the heterogeneity of immune infiltration within pedNST, our findings suggest personalized immunogenomic profiling is needed to guide selection of immunotherapeutic strategies.

Keyphrases

single cell
intensive care unit
emergency department
gene expression
transcription factor
heat shock
heat stress