Kinase Insert Domain Receptor Q472H Pathogenic Germline Variant Impacts Melanoma Tumor Growth and Patient Treatment Outcomes.
Milad IbrahimIrineu Illa-BochacaFaisal Fa'akKelsey R MonsonRobert FergusonChen LyuEleazar Vega-Saenz de MieraPaul JohannetMargaret ChouJustin MastroianniFarbod DarvishianTomas KirchhoffJudy ZhongMichelle KrogsgaardIman OsmanPublished in: Cancers (2023)
Our data demonstrate a role of germline KDR-Var in modulating melanoma behavior, including response to treatment. Our data also suggest that anti-angiogenic therapy might be beneficial in patients harboring this genotype, which needs to be tested in clinical trials.
Keyphrases
- clinical trial
- electronic health record
- newly diagnosed
- ejection fraction
- big data
- dna repair
- prognostic factors
- randomized controlled trial
- case report
- signaling pathway
- dna damage
- skin cancer
- machine learning
- stem cells
- bone marrow
- mesenchymal stem cells
- data analysis
- artificial intelligence
- deep learning
- phase ii
- smoking cessation