Enhanced RNA knockdown efficiency with engineered fusion guide RNAs that function with both CRISPR-CasRx and hammerhead ribozyme.
Yonghao ZhanCongcong CaoAolin LiHongbing MeiYuchen LiuPublished in: Genome biology (2023)
Thus, our study demonstrates that CCRS expands the design ideas and RNA knockdown capabilities of Cas13 technology and has the potential to be used in disease treatment.