Prostaglandins and calprotectin are genetically and functionally linked to the Inflammatory Bowel Diseases.
Mohamad KarakyGabrielle BoucherSaraï MolaSylvain FoisyClaudine BeauchampMarie-Eve RivardMelanie BurnetteHugues Gosselinnull nullAlain BittonGuy CharronPhilippe GoyetteJohn D RiouxPublished in: PLoS genetics (2022)
Our results support a causal role for the PTGIR, PTGER4, ZBTB40, SLC39A11 and NFKB1 genes in IBD, with all five genes regulating the expression of CP in myeloid cells, as well as potential roles for the prostacyclin/prostaglandin biogenesis and signaling pathways in IBD susceptibility and pathogenesis.
Keyphrases
- induced apoptosis
- genome wide
- signaling pathway
- poor prognosis
- genome wide identification
- bioinformatics analysis
- cell cycle arrest
- pulmonary arterial hypertension
- dendritic cells
- bone marrow
- acute myeloid leukemia
- ulcerative colitis
- oxidative stress
- dna methylation
- binding protein
- epithelial mesenchymal transition
- disease activity
- immune response
- long non coding rna
- systemic lupus erythematosus
- cell proliferation