PET quantification of brain O-GlcNAcase with [18F]LSN3316612 in healthy human volunteers.

Jae-Hoon LeeJeih-San LiowSoumen PaulCheryl L MorseMohammad B HaskaliLester ManlySergey ShcherbininJ Craig RubleNancy KantEmily C CollinsHugh N NuthallPaolo Zanotti-FregonaraSami S ZoghbiVictor W PikeRobert B Innis

Published in: EJNMMI research (2020)

[18F]LSN3316612 is an excellent PET radioligand for imaging O-GlcNAcase in the human brain. Alternative quantification without blood is possible, at least for within-subject repeat studies. However, the unexplained increase of VT under retest conditions requires further investigation.

Keyphrases

pet ct
positron emission tomography
computed tomography
endothelial cells
high resolution
pet imaging
white matter
induced pluripotent stem cells
resting state
pluripotent stem cells
case control
multiple sclerosis
mass spectrometry