Clinical Significance of Phosphorylated Sphingosine Kinase 1 Expression in Pancreatic Ductal Adenocarcinoma.

Hiroki NagaroHiroshi IchikawaKazuyasu TakizawaMasayuki NagahashiShun AbeYuki HiroseKazuki MoroKohei MiuraMasato NakanoYoshifumi ShimadaJun SakataToshifumi Wakai

Published in: Anticancer research (2023)

High pSphK1 expression is independently associated with lymphatic invasion and unfavorable prognosis in PDAC patients. Thus, the SphK1-S1P axis may be important in mechanisms of tumor progression, such as lymphatic invasion, in PDAC patients.

Keyphrases

end stage renal disease
poor prognosis
ejection fraction
chronic kidney disease
newly diagnosed
prognostic factors
lymph node
peritoneal dialysis
cell migration
patient reported outcomes
tyrosine kinase