Single-cell transcriptomics reveals multiple chemoresistant properties in leukemic stem and progenitor cells in pediatric AML.
Yongping ZhangShuting JiangFuhong HeYuanyuan TianHaiyang HuLi GaoLin ZhangAili ChenYixin HuLiyan FanChun YangBi ZhouDan LiuZihan ZhouYanxun SuLei QinYi WangHailong HeJun LuPeifang XiaoShaoyan HuQian-Fei WangPublished in: Genome biology (2023)
Our analysis reveals leukemia stem cell and OXPHOS as two major chemoresistant features in human AML patients. CD69 may serve as a potential biomarker in defining a subpopulation of chemoresistant leukemia stem cells. These findings have important implications for targeting residual chemo-surviving AML cells.
Keyphrases
- acute myeloid leukemia
- stem cells
- single cell
- end stage renal disease
- allogeneic hematopoietic stem cell transplantation
- ejection fraction
- induced apoptosis
- chronic kidney disease
- newly diagnosed
- rna seq
- cancer therapy
- peritoneal dialysis
- bone marrow
- cell therapy
- prognostic factors
- high throughput
- squamous cell carcinoma
- cell death
- nk cells
- pluripotent stem cells