Extracellular Vesicles as Therapeutic Resources in the Clinical Environment.
Jorge Sanz-RosCristina Mas-BarguesNekane Romero-GarcíaJavier Huete-AcevedoMar DromantConsuelo BorrásPublished in: International journal of molecular sciences (2023)
The native role of extracellular vesicles (EVs) in mediating the transfer of biomolecules between cells has raised the possibility to use them as therapeutic vehicles. The development of therapies based on EVs is now expanding rapidly; here we will describe the current knowledge on different key points regarding the use of EVs in a clinical setting. These points are related to cell sources of EVs, isolation, storage, and delivery methods, as well as modifications to the releasing cells for improved production of EVs. Finally, we will depict the application of EVs therapies in clinical trials, considering the impact of the COVID-19 pandemic on the development of these therapies, pointing out that although it is a promising therapy for human diseases, we are still in the initial phase of its application to patients.
Keyphrases
- induced apoptosis
- clinical trial
- cell cycle arrest
- end stage renal disease
- newly diagnosed
- ejection fraction
- chronic kidney disease
- endothelial cells
- endoplasmic reticulum stress
- single cell
- oxidative stress
- cell death
- stem cells
- cell therapy
- patient reported outcomes
- cell proliferation
- pi k akt
- double blind
- pluripotent stem cells