Targeting focal adhesion kinase boosts immune response in KRAS/LKB1 co-mutated lung adenocarcinoma via remodeling the tumor microenvironment.
Meng QiaoFei ZhouXinyu LiuTao JiangHaowei WangXuefei LiChao ZhaoLei ChengXiaoxia ChenShengxiang RenZaiqi WangCaicun ZhouPublished in: Experimental hematology & oncology (2024)
Our study identified FAK as a promising intervention target for KL tumors and provided basis for the combination of FAK inhibitor with PD-1 blockade in the management of KL lung cancers.