SEC23A confers ER stress resistance in gastric cancer by forming the ER stress-SEC23A-autophagy negative feedback loop.

Quan ChengKanghui LiuJian XiaoKuan ShenYuanhang WangXinyi ZhouJiawei WangZekuan XuLi Yang

Published in: Journal of experimental & clinical cancer research : CR (2023)

We reveal an ER stress-SEC23A-autophagy negative feedback loop that enhances the ability of gastric cancer cells to resist the adverse survival environments. These results identify SEC23A as a promising molecular target for potential therapeutic intervention and prognostic prediction in patients with gastric cancer.

Keyphrases

cell death
endoplasmic reticulum stress
signaling pathway
oxidative stress
randomized controlled trial
transcription factor
genome wide
gene expression
emergency department
dna methylation
electronic health record
adverse drug