Information in the published literature indicates that consumption of CBD can result in developmental and reproductive toxicity and hepatotoxicity outcomes in animal models. The trend of CBD-induced male reproductive toxicity has been observed in phylogenetically disparate organisms, from invertebrates to non-human primates. CBD has also been shown to inhibit various cytochrome P450 enzymes and certain efflux transporters, resulting in the potential for drug-drug interactions and cellular accumulation of xenobiotics that are normally transported out of the cell. The mechanisms of CBD-mediated toxicity are not fully understood, but they may involve disruption of critical metabolic pathways and liver enzyme functions, receptor-specific binding activity, disruption of testosterone steroidogenesis, inhibition of reuptake and degradation of endocannabinoids, and the triggering of oxidative stress. The toxicological profile of CBD raises safety concerns, especially for long term consumption by the general population.
Keyphrases
- oxidative stress
- diabetic rats
- dna damage
- oxide nanoparticles
- drug induced
- single cell
- endothelial cells
- systematic review
- healthcare
- ischemia reperfusion injury
- randomized controlled trial
- mesenchymal stem cells
- induced apoptosis
- risk assessment
- stem cells
- health information
- replacement therapy
- bone marrow
- gram negative
- multidrug resistant
- cell therapy
- social media
- adipose tissue
- smoking cessation
- skeletal muscle
- dna binding
- heat shock
- endoplasmic reticulum stress
- meta analyses