Western blot using Trypanosoma cruzi chimeric recombinant proteins for the serodiagnosis of chronic Chagas disease: A proof-of-concept study.
Ramona Tavares DaltroEmily Ferreira SantosÂngelo Antônio Oliveira SilvaNatália Erdens Maron FreitasLeonardo Maia LeonyLarissa Carvalho Medrado VasconcelosAlejandro Ostermayer LuquettiPaola Alejandra Fiorani CeledonNilson Ivo Tonin ZanchinCarlos Gustavo Regis-SilvaFred Luciano Neves SantosPublished in: PLoS neglected tropical diseases (2022)
The present phase I (proof-of-concept) study demonstrated the high diagnostic potential of these four IBMP antigens to discriminate between T. cruzi-positive and -negative samples, making them candidates for phase II and confirmatory testing with WB.