Phase I/II prospective clinical trial for the hybrid of intracavitary and interstitial brachytherapy for locally advanced uterine cervical cancer.

Naoya Murakami Miho Watanabe Nemoto Takashi Uno Shuhei Sekii Kayoko Tsujino Takahiro Kasamatsu Yumiko Machitori Tomomi Aoshika Shingo Kato Hisako Hirowatari Yuko Kaneyasu Tomio Nakagawa Hitoshi Ikushima Ken Ando Masumi Murata Ken Yoshida Hiroto Yoshioka Kazutoshi Murata Tatsuya Ohno Noriyuki Okonogi Anneyuko I Saito Mayumi Ichikawa Takahito Okuda Keisuke Tsuchida Hideyuki Sakurai Ryo-Ichi Yoshimura Yasuo Yoshioka Atsunori Yorozu Naonobu Kunitake Hiroyuki Okamoto Kouji Inaba Tomoyasu Kato Hiroshi Igaki Jun Itami

Published in: Journal of gynecologic oncology (2022)

The effectiveness of HBT were demonstrated by a prospective clinical study. Because the dose goal determined in the protocol was lower than 85 Gy, there is room in improvement for local control. A higher dose might have been needed for tumors with poor responses.

Keyphrases

clinical trial
randomized controlled trial
high dose
radiation therapy
systematic review
study protocol
low dose
phase ii