Evaluation of the IgG antibody response to SARS CoV-2 infection and performance of a lateral flow immunoassay: cross-sectional and longitudinal analysis over 11 months.
Louise J RobertsonJulie S MooreKevin BligheKok Yew NgNigel QuinnFergal JenningsGary WarnockPeter SharpeMark ClarkeKathryn MaguireSharon RaineyRuth K PriceWilliam P BurnsAmanda M KowalczykAgnes AwuahSara E McNameeGayle E WallaceDavid HunterSteve SagerConnie Chao ShernM Andrew NesbitJames A D McLaughlinC B Tara MoorePublished in: BMJ open (2021)
Through comprehensive analysis of a cohort of pre-pandemic and pandemic individuals, we show detectable levels of IgG antibodies, lasting over 46 weeks when assessed by EuroImmun ELISA, providing insight to antibody levels at later time points post-infection. We show good laboratory validation performance metrics for the AbC-19 rapid test for SARS-CoV-2 spike protein IgG antibody detection in a laboratory-based setting.