Evolving neoantigen profiles in colorectal cancers with DNA repair defects.

Giuseppe RospoAnnalisa LorenzatoNabil Amirouchene-AngelozziAlessandro MagrìCarlotta CancelliereGiorgio CortiCarola NegrinoVito AmodioMonica MontoneAlice BartoliniLudovic BaraultLuca NovaraClaudio IsellaEnzo MedicoAndrea BertottiLivio TrusolinoGiovanni GermanoFederica Di NicolantonioAlberto Bardelli

Published in: Genome medicine (2019)

These results indicate that CRCs carrying alterations in DNA repair pathways display dynamic neoantigen patterns that fluctuate over time. We define CRC subsets characterized by slow and fast evolvability and link this phenotype to downregulation of antigen-presenting cellular mechanisms. Longitudinal monitoring of the neoantigen landscape could be relevant in the context of precision medicine.

Keyphrases

dna repair
dna damage
dna damage response
cell proliferation
cross sectional
peripheral blood
case report
single cell
oxidative stress
childhood cancer