Login / Signup

Copper(I)-Catalyzed Enantioselective Intramolecular Aminotrifluoromethylation of O-Homoallyl Benzimidates.

Xue-Qing MouFeng-Ming RongHeng ZhangGong ChenGang He
Published in: Organic letters (2019)
In the present paper, the Cu(I)-catalyzed intramolecular aminotrifluoromethylation of O-homoallyl benzimidates with Togni reagent I was reported. O-Homoallyl benzimidates equipped with terminal alkenes produced chiral 1,3-oxazines with high enantioselectivity in the presence of a chiral BOX ligand, and racemic tetrahydro-1,3-oxazepines were obtained in high yields from internal alkene derivatives with a monoprotected amino acid additive under similar conditions.
Keyphrases
  • amino acid
  • room temperature
  • ionic liquid
  • capillary electrophoresis
  • transcription factor
  • energy transfer
  • binding protein