Sialidase NEU1 suppresses progression of human bladder cancer cells by inhibiting fibronectin-integrin α5β1 interaction and Akt signaling pathway.
Xiaoman ZhouYanhong ZhaiChangmei LiuGanglong YangJia GuoGuang LiChengwen SunXiaowei QiXiang LiFeng GuanPublished in: Cell communication and signaling : CCS (2020)
Our data showed that NEU1 inhibited cancer cell proliferation, induced apoptosis, and suppressed tumor formation both in vitro and in vivo, by disrupting interaction of FN and integrin β1 and inhibiting the Akt signaling pathway. Our observations indicate that NEU1 is an important modulator of the malignant properties of bladder cancer cells, and is a potential therapeutic target for prognosis and treatment of bladder cancer. Video Abstract.
Keyphrases
- signaling pathway
- induced apoptosis
- pi k akt
- cell proliferation
- spinal cord injury
- epithelial mesenchymal transition
- endothelial cells
- papillary thyroid
- cell cycle
- electronic health record
- endoplasmic reticulum stress
- urinary tract
- big data
- cell migration
- oxidative stress
- machine learning
- combination therapy
- climate change
- pluripotent stem cells
- smoking cessation
- replacement therapy
- young adults
- lymph node metastasis
- data analysis
- muscle invasive bladder cancer