Transcription dosage compensation does not occur in Down syndrome.

Samuel HunterJo HendrixJustin FreemanRobin D DowellMary A Allen

Published in: BMC biology (2023)

Transcription dosage compensation does not occur in Down syndrome. Simulated data containing no dosage compensation can appear to have dosage compensation when analyzed via standard methods. Moreover, some chromosome 21 genes that appear to be dosage compensated are consistent with allele specific expression.

Keyphrases

transcription factor
poor prognosis
gene expression
dna methylation
machine learning
big data
artificial intelligence