Protocol for the MicroRESUS study: The impact of circulatory shock and resuscitation on microcirculatory function and mitochondrial respiration after cardiovascular surgery.
John C GreenwoodFatima M TalebiDavid H JangAudrey E SpeldeTodd J KilbaughFrances S ShoferMichael A AckerJohn G T AugoustidesJan BakkerNuala J MeyerJacob S BrennerVladimir R MuzykantovBenjamin S AbellaPublished in: PloS one (2022)
This will be the first prospective study to examine both microcirculatory and mitochondrial function in human patients with circulatory shock undergoing cardiac bypass and address a key mechanistic knowledge gap in the cardiovascular literature. The results of this study will direct future research efforts and therapeutic development for patients with shock.